Patient-Derived Organoids Predict Treatment Response in Metastatic Colorectal Cancer

We identified predictors for successful mCRC PDO establishment and validated that PDOs can accurately predict patient outcomes during systemic treatment, specifically with 5-fluorouracil and oxaliplatin.

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Publication Details

Journal
Clinical Cancer Research
Published
2025-09-22
DOI
https://doi.org/10.1158/1078-0432.ccr-25-1564
Citations
5
Primary Topic
Cancer Cells and Metastasis
Type
article
Field-Weighted Citation Impact
5.23

Funders

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article

Patient-Derived Organoids Predict Treatment Response in Metastatic Colorectal Cancer

Manon N.G.J.A. Braat, Liselot Valkenburg‐van Iersel, Elske C. Gootjes, Onno Kranenburg et al.
5 citations
Clinical Cancer Research
Cancer Cells and Metastasis
5.23
article

Patient-Derived Organoids Predict Treatment Response in Metastatic Colorectal Cancer

Manon N.G.J.A. Braat, Liselot Valkenburg‐van Iersel, Elske C. Gootjes, Onno Kranenburg, G. Emerens Wensink, Timo Voskuilen, Hilde H. Nienhuis, Frank J. Jeurissen, Lidwien P. Smabers, Miriam Koopman, Guus Martinus Bol, Jeanine M.L. Roodhart, Geert A. Cirkel, Edwin Cuppen, Sjoerd G. Elias, Frederieke H. van der Baan, Sylvia F. Boj, Carla S. Verissimo, Maarten A. Huismans, Mayke Doorn, Henk M.W. Verheul, Robert G.J. Vries, Tao Yang
article en
5 citations

Abstract

We identified predictors for successful mCRC PDO establishment and validated that PDOs can accurately predict patient outcomes during systemic treatment, specifically with 5-fluorouracil and oxaliplatin.

Clinical Cancer ResearchVol. 31(23)
Radboud University Nijmegen (NL), Merck KGaA, Darmstadt (Germany) (DE), University of California, San Francisco (US), Utrecht University (NL), Maastricht University Medical Centre (NL), Erasmus MC (NL), Radboud University Medical Center (NL), University Medical Center Utrecht (NL), Maastricht University (NL), GGD Haaglanden (NL), Medisch Centrum Haaglanden (NL), SNV Netherlands Development Organisation (NL), Hubrecht Institute for Developmental Biology and Stem Cell Research (NL), Cancer Genomics Centre (NL), Hartwig Medical Foundation (NL), Meander Medisch Centrum (NL), UCSF Helen Diller Family Comprehensive Cancer Center (US), Erasmus University Rotterdam (NL)
Les Laboratories Pierre Fabre, Incyte, Universitair Medisch Centrum Utrecht, Servier, Dutch Colorectal Cancer Group
Openalex Percentile: Top 4%
Cancer Cells and Metastasis
5.23
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