Patient-Derived Organoids Predict Treatment Response in Metastatic Colorectal Cancer
We identified predictors for successful mCRC PDO establishment and validated that PDOs can accurately predict patient outcomes during systemic treatment, specifically with 5-fluorouracil and oxaliplatin.
Authors
- Manon N.G.J.A. Braat (ORCID: https://orcid.org/0000-0001-6580-4331)
- Liselot Valkenburg‐van Iersel (ORCID: https://orcid.org/0000-0003-2925-9908)
- Elske C. Gootjes (ORCID: https://orcid.org/0009-0000-9898-2767)
- Onno Kranenburg (ORCID: https://orcid.org/0000-0002-2112-4390)
- G. Emerens Wensink (ORCID: https://orcid.org/0000-0002-4103-5811)
- Timo Voskuilen (ORCID: https://orcid.org/0009-0000-4759-5177)
- Hilde H. Nienhuis (ORCID: https://orcid.org/0009-0003-6016-7814)
- Frank J. Jeurissen (ORCID: https://orcid.org/0009-0005-3881-1065)
- Lidwien P. Smabers (ORCID: https://orcid.org/0009-0007-9631-1012)
- Miriam Koopman (ORCID: https://orcid.org/0000-0003-1550-1978)
- Guus Martinus Bol (ORCID: https://orcid.org/0000-0002-4021-3823)
- Jeanine M.L. Roodhart (ORCID: https://orcid.org/0000-0003-1398-8970)
- Geert A. Cirkel (ORCID: https://orcid.org/0009-0007-8712-9825)
- Edwin Cuppen (ORCID: https://orcid.org/0000-0002-0400-9542)
- Sjoerd G. Elias (ORCID: https://orcid.org/0000-0003-3903-4024)
- Frederieke H. van der Baan (ORCID: https://orcid.org/0000-0002-7421-6547)
- Sylvia F. Boj (ORCID: https://orcid.org/0000-0002-6910-1083)
- Carla S. Verissimo (ORCID: https://orcid.org/0009-0009-2254-0968)
- Maarten A. Huismans (ORCID: https://orcid.org/0000-0003-1556-0820)
- Mayke Doorn (ORCID: https://orcid.org/0009-0002-2265-0672)
- Henk M.W. Verheul (ORCID: https://orcid.org/0000-0001-5981-922X)
- Robert G.J. Vries (ORCID: https://orcid.org/0009-0009-1408-1175)
- Tao Yang (ORCID: https://orcid.org/0009-0005-1162-0517)
Institutions
- Radboud University Nijmegen (NL)
- Merck KGaA, Darmstadt (Germany) (DE)
- University of California, San Francisco (US)
- Utrecht University (NL)
- Maastricht University Medical Centre (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- GGD Haaglanden (NL)
- Medisch Centrum Haaglanden (NL)
- SNV Netherlands Development Organisation (NL)
- Hubrecht Institute for Developmental Biology and Stem Cell Research (NL)
- Cancer Genomics Centre (NL)
- Hartwig Medical Foundation (NL)
- Meander Medisch Centrum (NL)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-1564
- Citations
- 5
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 5.23
Funders
- Les Laboratories Pierre Fabre
- Incyte
- Universitair Medisch Centrum Utrecht
- Servier
- Dutch Colorectal Cancer Group