Modification of Brain Connectome on Association Between Adverse Childhood Experiences and Development of Mental Disorders in Preadolescence
In this cohort study of children, a whole-brain functional connectivity score derived from neuroimaging data modified the association between ACEs and psychiatric disorders. This modification was particularly seen against threat-related ACEs and was pronounced for female youths. These findings suggest that functional connectivity strength in a broad system relevant to cognitive control may protect preadolescents who have experienced lifetime ACEs-especially girls and those experiencing threat-related ACEs-from developing transdiagnostic psychopathology.
Authors
- Eric A. Hoffman (ORCID: https://orcid.org/0000-0001-8456-9437)
- Laura Murray (ORCID: https://orcid.org/0000-0001-8409-4697)
- Betty Jo Salmeron (ORCID: https://orcid.org/0000-0003-1699-9333)
- Amy C. Janes (ORCID: https://orcid.org/0000-0002-3749-5006)
- Justine Hill (ORCID: https://orcid.org/0009-0009-2287-5776)
- Tianye Zhai (ORCID: https://orcid.org/0009-0009-2177-1465)
- Hong Gu (ORCID: https://orcid.org/0000-0001-6496-0383)
- Hanbing Lu
- Hieu Nguyen (ORCID: https://orcid.org/0000-0002-5154-0125)
- Thomas J. Ross (ORCID: https://orcid.org/0000-0002-7745-3572)
- Annika Quam
- Danni Wang (ORCID: https://orcid.org/0000-0002-1071-0888)
- Xiang Xiao (ORCID: https://orcid.org/0000-0002-2266-4284)
- Christopher J. Hammond (ORCID: https://orcid.org/0000-0003-3540-8201)
- Yihong Yang (ORCID: https://orcid.org/0009-0009-1925-9518)
Institutions
- National Institutes of Health (US)
- National Institute on Drug Abuse (US)
- Johns Hopkins University (US)
- Beijing Normal University (CN)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.33136
- Primary Topic
- Child and Adolescent Psychosocial and Emotional Development
- Type
- article
- Field-Weighted Citation Impact
- 0.00