Synergistic combination of imipenem and 7-fluoroindole inhibits β-lactamases and biofilm in Carbapenem-resistant <i>Acinetobacter baumannii</i>

The combination of 7-FI and imipenem synergistically mitigated carbapenem resistance in A. baumannii by inhibiting the activity of β-lactamases, downregulating the expression of β-lactamases and efflux pumps. The study shows 7-FI as a useful adjuvant to imipenem against CRAB strains.

Authors

Neena Capalash (ORCID: https://orcid.org/0000-0002-0197-8428)
Varsha Gupta
Prince Sharma
Vipasha Thakur
Anandita Chalana

Institutions

Government Medical College (IN)
Government Medical College and Hospital (IN)
Government Medical College and Hospital (IN)
Government Medical College (IN)
Panjab University (IN)

Publication Details

Journal: Journal of Applied Microbiology
Published: 2025-09-22
DOI: https://doi.org/10.1093/jambio/lxaf234
Primary Topic: Antibiotic Resistance in Bacteria
Type: article
Field-Weighted Citation Impact: 0.00

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article

Synergistic combination of imipenem and 7-fluoroindole inhibits β-lactamases and biofilm in Carbapenem-resistant Acinetobacter baumannii

Neena Capalash, Varsha Gupta, Prince Sharma, Vipasha Thakur et al.

Sep 22, 2025

Journal of Applied Microbiology

Antibiotic Resistance in Bacteria

article

Synergistic combination of imipenem and 7-fluoroindole inhibits β-lactamases and biofilm in Carbapenem-resistant Acinetobacter baumannii

Neena Capalash, Varsha Gupta, Prince Sharma, Vipasha Thakur, Anandita Chalana

September 22, 2025article en

Abstract

The combination of 7-FI and imipenem synergistically mitigated carbapenem resistance in A. baumannii by inhibiting the activity of β-lactamases, downregulating the expression of β-lactamases and efflux pumps. The study shows 7-FI as a useful adjuvant to imipenem against CRAB strains.

Journal of Applied MicrobiologyVol. 136(10)

Government Medical College (IN), Government Medical College and Hospital (IN), Government Medical College and Hospital (IN), Government Medical College (IN), Panjab University (IN)

Openalex Percentile: Top 79%

Antibiotic Resistance in Bacteria

DOI Source OpenAlex

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Synergistic combination of imipenem and 7-fluoroindole inhibits β-lactamases and biofilm in Carbapenem-resistant <i>Acinetobacter baumannii</i> — Neena Capalash, Varsha Gupta, et al. · Journal of Applied Microbiology (2025) | TGRS Research Map | TGRS