Adverse events of postoperative adjuvant chemotherapy predict survival outcomes in locally advanced colorectal cancer: a pooled analysis of Japanese clinical trials
The severity of adverse events during adjuvant chemotherapy correlated with survival outcomes in advanced colorectal cancer. Mild to moderate events were linked to improved prognosis, while absence suggested poorer outcomes, indicating a need for alternative treatments.
Authors
- Toru Aoyama (ORCID: https://orcid.org/0000-0001-6803-3800)
- Kosuke Kashiwabara (ORCID: https://orcid.org/0000-0003-3103-8055)
- Koji Oba (ORCID: https://orcid.org/0000-0001-5468-8988)
- Mitsuro Kanda (ORCID: https://orcid.org/0000-0001-5464-3819)
- Hidetaka Kawamura (ORCID: https://orcid.org/0000-0003-2396-0701)
- Takaki Yoshikawa (ORCID: https://orcid.org/0000-0003-1936-9484)
- Hiromichi Maeda (ORCID: https://orcid.org/0000-0001-7694-8082)
- Michitaka Honda (ORCID: https://orcid.org/0000-0003-3492-9881)
- Kenji Tanaka (ORCID: https://orcid.org/0000-0003-2320-4535)
- Shuhei Mayanagi (ORCID: https://orcid.org/0000-0002-0120-3497)
- Junichi Sakamoto
- Yujiro Nakayama
- Hisakazu Yamagishi
- Masaru Muto
Institutions
- Fukushima Medical University (JP)
- Tokyo Metropolitan Komagome Hospital (JP)
- Shizuoka Cancer Center (JP)
- University of Tokyo Hospital (JP)
- Japanese Foundation for Multidisciplinary Treatment of Cancer (JP)
- Shonan University of Medical Sciences (JP)
- National Cancer Center Hospital East (JP)
- Tokai Central Hospital (JP)
- Southern Tohoku General Hospital (JP)
- Japanese Foundation For Cancer Research (JP)
- Nagoya University (JP)
- The University of Tokyo (JP)
- Kōchi University (JP)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1038/s41416-025-03199-8
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00