Inhibition of GCKIII kinases STK25 and MST3 mitigates organ lipotoxicity and enhances metabolic resilience under nutritional stress
Dual inhibition of STK25 and MST3 in mice mitigates obesity-triggered lipotoxic injury to metabolic tissues and elevates indicators of BAT thermogenic capacity.
Authors
- Margit Mahlapuu (ORCID: https://orcid.org/0000-0001-8740-8874)
- Ingrid Wernstedt Asterholm (ORCID: https://orcid.org/0000-0002-0755-5784)
- Xiangdong Gongye (ORCID: https://orcid.org/0009-0001-1267-1835)
- Sheri Booten
- Bernice Asiedu (ORCID: https://orcid.org/0000-0001-6407-7566)
- Brian W. Howell (ORCID: https://orcid.org/0000-0002-0204-0773)
- Mara Caputo (ORCID: https://orcid.org/0000-0002-3362-9062)
- Johan Ruud
- Viktor Garellick
- Manoj Amrutkar (ORCID: https://orcid.org/0000-0002-1868-0249)
- Sue Murray (ORCID: https://orcid.org/0000-0002-7302-624X)
- Dan E. Lind (ORCID: https://orcid.org/0000-0002-8299-5659)
- Emmelie Cansby (ORCID: https://orcid.org/0000-0003-1589-3596)
- Ferran Font‐Gironès (ORCID: https://orcid.org/0000-0001-7474-0042)
- Jingjing Zhang (ORCID: https://orcid.org/0000-0002-1041-793X)
- Emma Andersson (ORCID: https://orcid.org/0000-0001-7382-9045)
Institutions
- Oslo University Hospital (NO)
- SUNY Upstate Medical University (US)
- Ionis Pharmaceuticals (United States) (US)
- Sahlgrenska University Hospital (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1186/s12916-025-04359-6
- Citations
- 1
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.16