Sex-dependent Schizophrenia and Drug Reward Behavioral Phenotypes in Metabotropic Glutamate 5 Receptor Heterozygous and Homozygous Mice
Our data demonstrate schizophrenia- and drug use-relevant phenotypes in mGlu5 HOMO mice, some of which are sex-dependent. These phenotypes do not occur in mGlu5 HET males and females. We also show for the first time an overgeneralization phenotype in mGlu5 HOMO mice, which may be related to poor contextual discrimination.
Authors
- Rossana Rosa Porto (ORCID: https://orcid.org/0000-0002-7292-6756)
- Anthony J. Hannan (ORCID: https://orcid.org/0000-0001-7532-8922)
- Fabian Kreilaus
- Rose Chesworth (ORCID: https://orcid.org/0000-0002-3758-9598)
- Tim Karl (ORCID: https://orcid.org/0000-0001-9904-8482)
Institutions
- Camden and Campbelltown Hospitals (AU)
- The University of Melbourne (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Western Sydney University (AU)
Publication Details
- Journal
- Schizophrenia Bulletin
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1093/schbul/sbaf161
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Western Sydney University