Relationship Between RAP and Multi-Modal Cerebral Physiological Dynamics in Moderate/Severe Acute Traumatic Neural Injury: A CAHR-TBI Multivariate Analysis
RAP relationships with other parameters remain consistent and differ meaningfully across compliance states. Integrating RAP into patient trajectory modelling and developing predictive frameworks based on these findings across different RAP states can map the evolution of cerebral physiology over time. This approach may improve prognostication and guide individualized interventions in TBI management. Therefore, these findings support RAP's potential as a valuable metric for bedside monitoring and its prospective role in guiding patient trajectory modeling and interventional studies in TBI.
Authors
- Françis Bernard (ORCID: https://orcid.org/0000-0001-9121-2882)
- François Mathieu (ORCID: https://orcid.org/0000-0002-7894-2466)
- Rahul Raj (ORCID: https://orcid.org/0000-0003-4243-9591)
- Logan Froese (ORCID: https://orcid.org/0000-0002-6076-0189)
- Kevin Y. Stein (ORCID: https://orcid.org/0000-0002-5983-008X)
- Donald Griesdale (ORCID: https://orcid.org/0000-0001-5985-8624)
- Andreas H. Kramer (ORCID: https://orcid.org/0000-0003-4008-4758)
- Abrar Islam (ORCID: https://orcid.org/0009-0006-6669-3374)
- Frederick Adam Zeiler (ORCID: https://orcid.org/0000-0003-1737-0510)
- Mypinder S. Sekhon (ORCID: https://orcid.org/0000-0002-4487-301X)
- Eric Peter Thelin (ORCID: https://orcid.org/0000-0002-2338-4364)
- Marcel Aries (ORCID: https://orcid.org/0000-0001-5327-1275)
- Clare Gallagher (ORCID: https://orcid.org/0000-0001-5459-2476)
Institutions
- Karolinska University Hospital (SE)
- University of Helsinki (FI)
- University of British Columbia (CA)
- University of Calgary (CA)
- University of Toronto (CA)
- Maastricht University Medical Centre (NL)
- Helsinki University Hospital (FI)
- Karolinska Institutet (SE)
- Maastricht University (NL)
- Pan Am Clinic (CA)
- Hotchkiss Brain Institute (CA)
- University of Manitoba (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Bioengineering
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3390/bioengineering12091006
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Sciences Centre Foundation
- Research Manitoba
- Karolinska Institutet
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada