Non‐Response to Obeticholic Acid Is Associated With Heightened Risks of Developing Clinical Events in Primary Biliary Cholangitis
Biochemical response stratifies risk of clinical events in PBC patients under OCA treatment. Whilst response rates increase over time, discontinuation rates underscore the need for newer treatment paradigms.
Authors
- James Ferguson (ORCID: https://orcid.org/0000-0002-2529-0409)
- Douglas Thorburn (ORCID: https://orcid.org/0000-0002-5610-5448)
- Aldo J. Montaño‐Loza (ORCID: https://orcid.org/0000-0002-2511-7980)
- Amal Almahroos
- Marco Carbone (ORCID: https://orcid.org/0000-0003-1445-0443)
- Emma Louise Culver (ORCID: https://orcid.org/0000-0001-9644-8392)
- George F. Mells (ORCID: https://orcid.org/0000-0002-7962-5286)
- Nadia Eden
- Palak Trivedi (ORCID: https://orcid.org/0000-0002-4009-8087)
- Pietro Invernizzi (ORCID: https://orcid.org/0000-0003-3262-1998)
- Nadir Abbas (ORCID: https://orcid.org/0000-0002-8847-7713)
- Sanchit Sharma (ORCID: https://orcid.org/0000-0002-3204-3721)
- Neil Halliday (ORCID: https://orcid.org/0000-0001-8220-9139)
- Jessica Dyson (ORCID: https://orcid.org/0000-0001-6733-5225)
- Rachel A. Smith (ORCID: https://orcid.org/0000-0003-2407-7515)
- David Jones (ORCID: https://orcid.org/0000-0002-2036-5141)
- Ellina Lytvyak
- Miki Scraravaglio
- Diane Lloyd‐Madden
Institutions
- University of Alberta (CA)
- Royal Free London NHS Foundation Trust (GB)
- University of Cambridge (GB)
- Queen Elizabeth Hospital Birmingham (GB)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- John Radcliffe Hospital (GB)
- University of Alberta Hospital (CA)
- NIHR Birmingham Liver Biomedical Research Unit (GB)
- Institut de Recherche en Santé Digestive (FR)
- Institute of Immunology (HR)
- NIHR Newcastle Biomedical Research Centre (GB)
- ERN GUARD-Heart (NL)
- Immune Regulation (United Kingdom) (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
- Institute of Infection and Immunity (CA)
- University College London (GB)
- University of Milano-Bicocca (IT)
- Newcastle University (GB)
Publication Details
- Journal
- Alimentary Pharmacology & Therapeutics
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1111/apt.70378
- Citations
- 3
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 3.97
Funders
- National Institute for Health and Care Research