Beyond prevalence: rethinking climate-driven risk for cholelithiasis in a warming world

Cholelithiasis, also known as a gallbladder stone, is a significant health issue that contributes to the global health burden, affecting millions of people worldwide. Many risk factors have already been identified, but seasonal variations, especially in summer, where the surge of cases is seen, are less explored. It is also noteworthy that global warming is not only the hazardous factor for climate which can lead to long hot seasons but also for the health of living beings, in humans, it can cause heat strokes, and if sustained it increase the risk of renal stones, and gallstones by various mechanism such as dehydration. This letter aims to address the potential link between the climate and cholelithiasis and an urgent call for health authorities to deal with it efficiently and accordingly.