High-sensitivity C-reactive protein as an early transdiagnostic biomarker for thoughts of death in mood disorders

Our findings suggest that hsCRP could potentially represent a relatively easy, cheap and early transdiagnostic inflammatory biomarker for suicidality across mood disorders, particularly among those displaying a predominant affective depressive temperament. Further studies should longitudinally explore clinical implication derived by the stratification of mood disorders according to the inflammatory pattern, as well as testing whether anti-inflammatory therapy could represent an early treatment strategy for managing suicidality risk.