Maternal Dietary Inflammatory Index and Biomarkers of Inflammation at Birth
We evaluated the association between the inflammatory potential of the maternal diet during pregnancy and levels of inflammatory biomarkers measured in cord blood and maternal serum at birth. Dietary inflammatory potential was calculated using the energy-adjusted dietary inflammatory index (E-DII) in the French EDEN and ELFE birth cohorts. Biomarkers of inflammation (interleukin [IL]-1β, IL-6, IL-10, tumor necrosis factor α [TNF-α]) were measured from cord blood (EDEN [n = 758]; ELFE [n = 899]) and maternal serum (in ELFE only; [n = 911]) collected at birth. Additionally, leptin was also measured from cord blood in EDEN (n = 1202) and C-reactive protein was measured from cord blood in ELFE (n = 895). Linear regression models, adjusted for confounders, were used to investigate the association between tertiles of the E-DII score and each log-transformed biomarker. There were no significant associations between the E-DII score and maternal or cord blood biomarkers in either cohort. The energy-adjusted dietary inflammatory index score during pregnancy was not associated with concentrations of inflammatory biomarkers in either maternal serum or cord blood at birth.
Authors
- Susana Barbosa (ORCID: https://orcid.org/0000-0002-7486-9097)
- Laëtitia Davidovic (ORCID: https://orcid.org/0000-0002-1507-5625)
- Olfa Khalfallah (ORCID: https://orcid.org/0000-0002-9093-1591)
- Cédric Galera (ORCID: https://orcid.org/0000-0003-0549-9608)
- Courtney Dow (ORCID: https://orcid.org/0000-0002-9925-8460)
- Marie-Aline A Charles (ORCID: https://orcid.org/0000-0003-4025-4390)
- Rosalie Delvert (ORCID: https://orcid.org/0000-0002-1524-8071)
- Blandine de Lauzon‐Guillain (ORCID: https://orcid.org/0000-0001-5887-8842)
- Judith van der Waerden (ORCID: https://orcid.org/0000-0002-5324-1372)
- Barbara Heude
Institutions
- Université Paris-Sud (FR)
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Inserm (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Paris Cité (FR)
- Université Paris-Saclay (FR)
- Sorbonne Université (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Université Sorbonne Paris Nord (FR)
- Sorbonne Paris Cité (FR)
- Research Unit on Children's Psychosocial Maladjustment (CA)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- Bordeaux Population Health (FR)
- Institut Pierre Louis d‘Épidémiologie et de Santé Publique (FR)
- Centre Hospitalier Charles Perrens (FR)
- Institut de Pharmacologie Moléculaire et Cellulaire (FR)
- Centre de Recherche Épidémiologie et Statistique (FR)
Publication Details
- Journal
- Maternal and Child Nutrition
- Published
- 2025-09-21
- DOI
- https://doi.org/10.1111/mcn.70108
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00