Tumour budding and tumour-stroma ratio in hepatocellular carcinoma
Tumour budding was an independent risk factor for disease-specific mortality in surgically treated HCC patients, with higher bud counts indicating poorer outcomes. Tumour buds were consistently found across slides. Furthermore, our results suggest that tumour buds are most reliably evaluated using resection samples.
Authors
- Juha Saarnio (ORCID: https://orcid.org/0000-0002-8443-3625)
- Olli Helminen (ORCID: https://orcid.org/0000-0001-9544-6475)
- Jan Böhm (ORCID: https://orcid.org/0000-0001-9664-588X)
- Joonas H. Kauppila (ORCID: https://orcid.org/0000-0001-6740-3726)
- Valtteri Kairaluoma (ORCID: https://orcid.org/0000-0003-2399-3722)
- Juha P. Väyrynen (ORCID: https://orcid.org/0000-0002-8683-2996)
- Heikki Huhta (ORCID: https://orcid.org/0000-0002-6273-198X)
- Niklas Sarelin
Institutions
- Karolinska University Hospital (SE)
- Oulu University Hospital (FI)
- Central Finland Health Care District (FI)
Publication Details
- Journal
- Human Pathology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1016/j.humpath.2025.105937
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00