Personalized aerosolized bacteriophage treatment of a pulmonary infection due to carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae in an infant
A 9-month-old ICU patient with persistent carbapenem-resistant Acinetobacter baumannii pneumonia developed a secondary infection of carbapenem-resistant Klebsiella pneumoniae. A customized, preoptimized phage cocktail was administered twice daily for 3 consecutive days, resulting in eradication of the pathogens and reduction in their abundance in the lung and gut microbiota.
Authors
- Caiyan Zhang (ORCID: https://orcid.org/0000-0001-6117-9807)
- Gangfeng Yan
- Aibing Jin (ORCID: https://orcid.org/0000-0002-3222-7336)
- Weili Yang (ORCID: https://orcid.org/0000-0002-2281-6073)
- Qian Yang
- Nannan Wu (ORCID: https://orcid.org/0000-0003-1244-0030)
- Guoping Lu
- Chuanqing Wang (ORCID: https://orcid.org/0000-0002-0158-9094)
- Zhenyu Zhang (ORCID: https://orcid.org/0000-0001-5570-090X)
- Weiming Chen (ORCID: https://orcid.org/0000-0003-4868-1602)
- Jinlan Zhou
- Jianfang Liu (ORCID: https://orcid.org/0000-0001-6786-8873)
- Yixue Wang (ORCID: https://orcid.org/0009-0005-5596-8507)
- Huiyuan Yan
- Leiyan He
- Mengjun Cheng (ORCID: https://orcid.org/0000-0002-3271-7589)
Institutions
- Fudan University (CN)
- Shanghai CASB Biotechnology (China) (CN)
- Shanghai Public Health Clinical Center (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Children's Hospital of Fudan University (CN)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.ijid.2025.108075
- Citations
- 1
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- National Natural Science Foundation of China