PIGK regulates lipophagy in colorectal cancer through ABHD5
In summary, our findings not only highlight PIGK as a novel molecular target in CRC but also suggest that targeting the PIGK-ABHD5-PPARα signaling axis could offer a promising therapeutic strategy. By influencing lipophagy, PIGK presents a potential avenue for improving CRC treatment outcomes, which could have significant implications for patient management and the development of new treatment protocols.
Authors
- Xiulei Zhang (ORCID: https://orcid.org/0000-0002-0596-6715)
- Haifeng Guo
- Jiannan Wang (ORCID: https://orcid.org/0000-0003-3312-6833)
- Xiaofang Li (ORCID: https://orcid.org/0000-0003-1554-4484)
- Yuan Yuan (ORCID: https://orcid.org/0000-0001-9974-0516)
- Qian Zhang (ORCID: https://orcid.org/0000-0003-4928-3366)
- Zhiyu Yang (ORCID: https://orcid.org/0009-0001-4666-5935)
- Di Lu
- Bingxi Zhou
Institutions
- Zhengzhou University (CN)
- Henan Provincial People's Hospital (CN)
Publication Details
- Journal
- Cellular Signalling
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1016/j.cellsig.2025.112147
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80