LRRc17-RANKL pathway regulates mitophagy and contributes to atrial remodeling in diabetes
In atrial myocytes, mitophagy is mediated by the LRRc17-RANKL pathway. Diabetes induced atrial remodeling may worsen due to the overexpression of RANKL brought on by the decrease in LRRc17. The LRRc17-RANKL pathway may be a therapy option for diabetic atrial remodeling by improving mitochondrial function.
Authors
- Qiankun Bao (ORCID: https://orcid.org/0000-0002-5221-2780)
- Gregory Y.H. Lip (ORCID: https://orcid.org/0000-0002-7566-1626)
- Gary Tse (ORCID: https://orcid.org/0000-0001-5510-1253)
- Qingmiao Shao
- Daiqi Liu
- Ziheng Jia
- Zandong Zhou
- Xinyi Gao (ORCID: https://orcid.org/0000-0002-3678-1182)
- Lu Zhou (ORCID: https://orcid.org/0000-0002-5464-5176)
- Tong Liu (ORCID: https://orcid.org/0009-0003-5877-2783)
- Wenhua Song
Institutions
- Second Hospital of Tianjin Medical University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Cellular Signalling
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1016/j.cellsig.2025.112148
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00