Multi-omics reveals efferocytosis-related hub genes as biomarkers for ustekinumab response in colitis
This study reveals cellular heterogeneity at different stages of efferocytosis in UC, identifies efferocytosis-related genes as critical regulators of mucosal repair and predictors of UST efficacy. Findings emphasize targeting macrophage-driven efferocytosis to resolve inflammation, offering novel strategies for improving treatment outcomes.
Authors
- Jun‐Meng Wang (ORCID: https://orcid.org/0000-0003-3771-4026)
- Jing Yuan (ORCID: https://orcid.org/0000-0003-1219-3316)
- Wan-Yu Xia
- Yu-sha Liao
Institutions
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1597528
- Citations
- 2
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.59