The postbiotic of hawthorn-probiotic ameliorates constipation by multi-pathway inhibition of PANoptosis in intestinal epithelial cells
Postbiotic of hawthorn-probiotic demonstrates efficacy in alleviating constipation through the multi-pathway inhibition of apoptosis and pyroptosis, alongside the remodeling of the immune microenvironment. Its multi-target mechanism and favorable safety profile position it as a promising therapeutic candidate. These findings lay a solid foundation for the development of interventions based on hawthorn-probiotic postbiotics for constipation and related gastrointestinal disorders.
Authors
- Shiying Chen (ORCID: https://orcid.org/0000-0003-1572-9630)
- Yali Huang (ORCID: https://orcid.org/0009-0004-3330-6978)
- Shide Lin (ORCID: https://orcid.org/0000-0001-8803-4069)
- Cong Zhang (ORCID: https://orcid.org/0000-0001-6017-4326)
- Jieling Lin
- Yu Wei (ORCID: https://orcid.org/0000-0002-3912-3804)
- Mingtao Huang
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Southern University of Science and Technology (CN)
- First People's Hospital of Foshan (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1622619
- Citations
- 1
- Primary Topic
- Antioxidants, Aging, Portulaca oleracea
- Type
- article
- Field-Weighted Citation Impact
- 0.91