EGCG Metal–Polyphenol Frameworks for Controlling Nitric Oxide Release in the Treatment of MRSA-Infected Wounds

Drug-resistant bacteria have become the main pathogens in hospitals. Due to their resistance, traditional antibiotics are increasingly limited in treating resistant bacteria. To overcome this problem, a metal-polyphenol framework (MPN) loaded with a nitric oxide donor (S-nitrosoglutathione (GSNO)) was designed for the treatment of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA)-infected wounds. The MPN forms a framework structure through chelation between epigallocatechin gallate (EGCG) and Fe³⁺, encapsulating the GSNO. The results demonstrated that under 808 nm laser irradiation, the photothermal-triggered release of NO could inhibit MRSA and eliminate biofilms. EGCG has the ability to scavenge ROS and inhibit inflammation, effectively inducing macrophage polarization from M1 to M2, promoting angiogenesis and wound healing. In summary, this work designed a simple and effective drug delivery system, providing a promising therapeutic strategy for controlling MRSA infection and promoting tissue regeneration.