Single-nucleus RNA sequencing reveals cellular and molecular signatures in the prefrontal cortex of a hypoactive sexual desire disorder rat model
We have established a stable translational model of HSDD through rigorous screening and validation, demonstrating specific molecular and cellular alterations in the PFC of model rats characterized by: (1) excitatory-inhibitory neuronal imbalance, (2) microglial activation indicative of neuroimmune dysregulation, and (3) OPC maturation deficits.
Authors
- Mengyue Chen (ORCID: https://orcid.org/0000-0002-6482-5381)
- Bing Song (ORCID: https://orcid.org/0000-0002-7182-0175)
- Guanjian Li (ORCID: https://orcid.org/0000-0001-9296-0372)
- Lirui Guan
- Xiaojin He (ORCID: https://orcid.org/0000-0001-5919-8478)
- Chao Wang (ORCID: https://orcid.org/0000-0002-6720-6586)
- Ping Zhou
- Lu Zhu (ORCID: https://orcid.org/0000-0001-8797-2811)
Institutions
- Anhui University (CN)
- Anhui Medical University (CN)
- Shanghai Mental Health Center (CN)
- Health Commission of Anhui Province (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- The Journal of Sexual Medicine
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1093/jsxmed/qdaf138
- Citations
- 2
- Primary Topic
- Neuroendocrine regulation and behavior
- Type
- article
- Field-Weighted Citation Impact
- 4.88