FLAG-IDA plus venetoclax for children, adolescents, and young adults with newly diagnosed AML
FLAG-IDA (fludarabine, cytarabine, granulocyte colony-stimulating factor, idarubicin) with venetoclax shows promise as frontline pediatric acute myeloid leukemia therapy. In 12 patients treated at MD Anderson, most achieved remission with good early survival outcomes, and many proceeded to transplant. Common toxicities included cytopenias, comparable to previous regimens.
Authors
- Samanta Catueno (ORCID: https://orcid.org/0000-0002-0072-8603)
- Courtney Denton Dinardo (ORCID: https://orcid.org/0000-0001-9003-0390)
- Alexandra McLean Stevens (ORCID: https://orcid.org/0000-0002-7292-2464)
- Irtiza Sheikh
- Priti Tewari
- Tapan Mahendra Kadia (ORCID: https://orcid.org/0000-0002-9892-9832)
- Koji Sasaki (ORCID: https://orcid.org/0000-0002-9140-0610)
- Miriam B. Garcia (ORCID: https://orcid.org/0000-0002-2978-2267)
- Álex Bataller (ORCID: https://orcid.org/0000-0002-6085-2745)
- Naval Guastad Daver (ORCID: https://orcid.org/0000-0001-7103-373X)
- Michael Roth (ORCID: https://orcid.org/0000-0002-6411-8353)
- Branko Cuglievan (ORCID: https://orcid.org/0000-0002-6917-2244)
- Ghayas C. Issa (ORCID: https://orcid.org/0000-0002-4339-8683)
- Jeremy Connors (ORCID: https://orcid.org/0000-0003-2817-8890)
- David McCall (ORCID: https://orcid.org/0000-0003-2297-9670)
- Kapil N. Bhalla (ORCID: https://orcid.org/0000-0001-5209-5126)
- Amber Gibson (ORCID: https://orcid.org/0000-0002-9146-4702)
- Reeja Raj
- César Núnêz (ORCID: https://orcid.org/0000-0002-9701-8826)
- Demetrios Petropoulos (ORCID: https://orcid.org/0000-0003-0453-247X)
- Yuki Nishida
- Aziz Farhat
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Baylor College of Medicine (US)
Publication Details
- Journal
- Blood
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1182/blood.2025029391
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00