Immunomodulators and Advanced Therapies for Induction of Remission in Crohn’s Disease: A Systematic Review and Network Meta-Analysis
Combination of anti-tumor necrosis factors (anti-TNFs) and immunomodulators followed by anti-TNF monotherapy had large effect size with moderate certainty for the induction of clinical remission. More novel therapies appear to have similar effect sizes but with increased imprecision of the estimates.
Authors
- Aderonke Ajiboye (ORCID: https://orcid.org/0000-0001-5989-9522)
- Morris A. Gordon (ORCID: https://orcid.org/0000-0002-1216-5158)
- Shellie Jean Radford (ORCID: https://orcid.org/0000-0002-2226-0810)
- Gordon W. Moran (ORCID: https://orcid.org/0000-0002-8906-6908)
- Vassiliki Sinopoulou (ORCID: https://orcid.org/0000-0002-2831-9406)
- Sudheer Kumar Vuyyuru (ORCID: https://orcid.org/0000-0002-8281-3237)
- Shiyao Liu (ORCID: https://orcid.org/0000-0002-5245-1810)
- Deijanira Albuquerque (ORCID: https://orcid.org/0000-0003-1539-8798)
Institutions
- University of Nottingham (GB)
- University of Lancashire (GB)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-07-25
- DOI
- https://doi.org/10.1093/ibd/izaf191
- Citations
- 2
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 3.63