World first hybrid neuroendocrine cell line sharing properties of NET G3 and dedifferentiated NEC
The MS-18 cell line is the first patient-derived cell line with a transitional phenotype between differentiated NET and dedifferentiated NEC, showing strong expression of SSTR2 and CXCR4 and absence of driver mutations in key NET-/NEC-associated genes. It offers a unique platform for preclinical evaluation of targeted therapies.
Authors
- Philipp E. Hartrampf (ORCID: https://orcid.org/0000-0001-5622-9849)
- Christian Stigloher (ORCID: https://orcid.org/0000-0001-6941-2669)
- Surasak Jittavisutthikul
- Rudolf Alexander Werner (ORCID: https://orcid.org/0000-0003-3372-6046)
- Szn Yi Chan (ORCID: https://orcid.org/0000-0002-1834-4392)
- Silvia Gulden (ORCID: https://orcid.org/0000-0002-4309-6626)
- Laura‐Sophie Landwehr (ORCID: https://orcid.org/0000-0002-6315-4176)
- Elena Hartmann (ORCID: https://orcid.org/0000-0003-2134-2774)
- Alexander Weich (ORCID: https://orcid.org/0000-0002-4127-1347)
- Alexander Meining
- L. Frey (ORCID: https://orcid.org/0000-0003-4696-4326)
- Thomas G.P. Bumm
- Dorothee Rogoll (ORCID: https://orcid.org/0000-0002-7080-0471)
- Michael Scheurlen
- Jochen Schreiner
- Cheng Wen-Hui
- Hayley Schnaidt
Institutions
- University of Würzburg (DE)
- Universitätsklinikum Würzburg (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1093/ejendo/lvaf159
- Citations
- 1
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.01