Development and application of a multimatrix LC–MS/MS method for quantifying elexacaftor–tezacaftor–ivacaftor: Expanding therapeutic drug monitoring in cystic fibrosis from systemic circulation to airways and sweat
This integrated analytical approach provides a holistic view of systemic and local ETI distribution, increasing the potential for personalized TDM, pharmacokinetics/pharmacodynamics study, and optimization of CFTR modulator therapy.
Authors
- Matteo Mucci (ORCID: https://orcid.org/0000-0003-0417-0720)
- Maria Di Sabatino
- Antonio Recchiuti (ORCID: https://orcid.org/0000-0002-1409-5261)
- Marta Di Nicola (ORCID: https://orcid.org/0000-0003-1748-1931)
- Mario Romano (ORCID: https://orcid.org/0000-0001-8512-1458)
- Francesca Collini (ORCID: https://orcid.org/0000-0001-9694-9111)
- Pietro Ripani (ORCID: https://orcid.org/0000-0003-0789-2745)
- Martina Colarelli
- Marianna Del Ciotto
Institutions
- University of Teramo (IT)
- University of Chieti-Pescara (IT)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1016/j.biopha.2025.118558
- Citations
- 1
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 1.52