DBU-Promoted (4 + 1) Annulation of Donor–Acceptor Cyclopropanes with 3-Phenylisoxazol-5(4<i>H</i>)-one: Access to Spiroisoxazol-5(4<i>H</i>)-one Derivatives
A DBU-promoted (4 + 1)-annulation reaction between donor-acceptor (D-A) cyclopropanes and 3-phenylisoxazolone has been developed. Using this method, some valuable spiroisoxazol-5(4H)-one derivatives can be obtained easily in good yields. This protocol features producing highly stereospecific products, atomic economy, mild reaction conditions, and good efficiency, constituting an array of spiroisoxazol-5(4H)-ones.
Authors
- Cunde Wang (ORCID: https://orcid.org/0000-0001-5561-979X)
- Yuhang Xue
- Lizhong Wang (ORCID: https://orcid.org/0000-0002-3571-8771)
- Jiaming Liu (ORCID: https://orcid.org/0000-0002-4960-8813)
- Wenzhe Cheng
Institutions
- Intelligent Health (United Kingdom) (GB)
- Taizhou Vocational and Technical College (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1021/acs.joc.5c01599
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00