Co-activation of the super-enhancer complex SOX2 and HDAC1 confers temozolomide resistance by promoting PDGFB transcription in glioblastoma
Targeting the SE complex enhances TMZ chemosensitivity in GBM, providing a promising therapeutic avenue to overcome drug resistance and improve clinical outcomes.
Authors
- Jingzhe Wang (ORCID: https://orcid.org/0000-0001-8332-7997)
- Siyi Xu (ORCID: https://orcid.org/0000-0002-5147-2644)
- Meng Cheng (ORCID: https://orcid.org/0000-0001-7600-1809)
- Tongjie Ji
- Yueyao Wu (ORCID: https://orcid.org/0000-0001-5140-8223)
- Han Xie (ORCID: https://orcid.org/0000-0002-2089-5644)
- Junyu Yang (ORCID: https://orcid.org/0000-0002-6275-513X)
- Rui Wang (ORCID: https://orcid.org/0000-0002-6622-8134)
- Min Liu (ORCID: https://orcid.org/0000-0003-3965-846X)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-4825-9674)
- Chunyu Zhang (ORCID: https://orcid.org/0000-0003-0448-1756)
- Honghao Wang (ORCID: https://orcid.org/0000-0002-1215-6219)
- Chunlong Zhong (ORCID: https://orcid.org/0000-0002-0605-7273)
Institutions
- Tongji University (CN)
- Shanghai East Hospital (CN)
- State Key Laboratory of Cardiovascular Disease
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1093/neuonc/noaf219
- Citations
- 2
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.25