Palladium-Catalyzed Synthesis of Quinolinyl Lactones via Double C(sp<sup>3</sup>)–H Functionalization
We have developed a novel palladium-catalyzed method for synthesizing quinolinyl lactones via double C(sp<sup>3</sup>)-H functionalization. This atom-economical strategy utilizes a bifunctional 2-iodobenzoic acid reagent in a single catalytic cycle. An optimized solvent mixture of hexafluoro-2-propanol and acetic acid significantly enhanced reactivity and selectivity. This work provides a valuable, site-selective pathway for creating complex quinolinyl lactone scaffolds.
Authors
- Mahesh A. Sonawane
- Subhash Chandra Ghosh (ORCID: https://orcid.org/0000-0002-6528-1582)
- Dinesh Gopichand Thakur (ORCID: https://orcid.org/0000-0002-3084-1236)
- Raj N. Patel (ORCID: https://orcid.org/0000-0002-5303-527X)
Institutions
- Central Salt and Marine Chemicals Research Institute (IN)
- CTS Corporation (Czechia) (CZ)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1021/acs.orglett.5c03411
- Citations
- 2
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.61