N-formyl methionine peptide-driven neutrophil activation in idiopathic inflammatory myopathies
Our findings show that fMET-FPR1 signalling drives neutrophil activation in DM and IBM, promoting inflammation and muscle damage. Targeting this pathway may offer a novel IIM therapy.
Authors
- Ingrid E. Lundberg (ORCID: https://orcid.org/0000-0002-6068-9212)
- Antonella Notarnicola (ORCID: https://orcid.org/0000-0003-0272-2931)
- Inger Nennesmo (ORCID: https://orcid.org/0009-0000-0871-1147)
- Jorge A. González-Chapa (ORCID: https://orcid.org/0000-0001-5231-2469)
- Ryan D. Stultz (ORCID: https://orcid.org/0000-0003-1859-9181)
- NAVEDEEP KAUR
- Begum Horuluoglu (ORCID: https://orcid.org/0000-0003-2241-5170)
- Christian Lood (ORCID: https://orcid.org/0000-0002-6171-1952)
- Lisa Christopher‐Stine (ORCID: https://orcid.org/0000-0002-7150-7306)
- Jemima Albayda (ORCID: https://orcid.org/0000-0002-8030-9504)
- Arpit Rathee
Institutions
- Karolinska University Hospital (SE)
- Johns Hopkins University (US)
- University of Washington (US)
- Johns Hopkins Medicine (US)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1093/rheumatology/keaf495
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00