Study of Anti-Efficacy of Antimony Hydroxide Extracted From Eyeliner in Resistant Staphylococcus Aureus Bacteria Isolated From Conjunctival Infections in Patients of Karbala Governorate

Staphylococcus aureus is a major cause of bacterial eye inflammation, an inflammation that can lead to severe vision impairment if not treated immediately. The use of antimony solution is due to the presence of antimony Sb, antimony compounds are used to treat schistosomiasis and leishmaniasis, but in this study it was used as a growth-inhibiting antibacterial against isolates of resistant S. aureus isolated from conjunctival infections, and this study was the first of its kind. This study aims to find out the effect of antimony hydroxide extracted from eyeliner on bacteria isolated from conjunctival injuries. This came after reviewing previous studies related to conjunctival infections and the microorganisms that affect them and their danger to the individual. Materials and methods Samples were collected from patients with bacterial conjunctivitis of patients arriving at Imam Hassan al-Mojtaba educational hospital and Al-Hindi educational hospital in Karbala governorate ranging in age from (5-75 years) for both sexes and for the period from November 2024 to February. 2025, extraction of antimony hydroxide from the eyeliner and evaluating it as an inhibitor of the growth of staphylococcal bacteria. Results: the resistance of staphylococci to the antibiotic rifampicin, clindamycin and teicoplanin is eighty-eight. 89%, benzepenicillin and vancomycin 100%, Oxacillin 77.78%, erythromycin 55.56%, sensitivity to gentamicin, ciprofloxacin, moxifloxacin, and trimethoprim 100%, tetracycline 88.89% and fusidic acid 77.78%. The use of antimony hydroxide extracted from the eyeliner of the fruit in inhibiting the growth of staphylococci at different concentrations (75, 150 , 300 mg/mL) and it has been found that the strongest inhibition of it at a concentration of 300 mg /mL and MIC =75mg/ml and a value of .MBC=150mg/ml Conclusions: antimony hydroxide has an inhibitory effect on the growth of staphylococcal bacteria and may be used as a natural alternative or supplement to conventional antibiotics, especially considering the resistance of some strains of staphylococci to antibiotics such as MRSA. This inhibitory effect is due to antimony hydroxide itself, which is known for its toxic properties to bacteria by interfering with cell walls or their vital processes.