Time trends, uptake, and oncological effects of risk-reducing surgeries in 3067 Danish BRCA1/2 carriers: a population-based study with matched controls
BRRM's large protective effect against breast cancer in BRCA1/2 carriers was confirmed, in contrast to that of RR-BSO. There were tendencies toward a reduction in overall mortality rates after BRRM, and compared with controls, we saw tendencies toward higher mortality rates before BRRM.
Authors
- Lene Mellemkjær (ORCID: https://orcid.org/0000-0001-9222-6215)
- Cecilie Balslev Willert (ORCID: https://orcid.org/0000-0001-5255-8346)
- Susanne Rosthøj (ORCID: https://orcid.org/0000-0002-3619-413X)
- Anders Tolver (ORCID: https://orcid.org/0000-0003-1109-9889)
- Pernille Envold Bidstrup (ORCID: https://orcid.org/0000-0002-9704-6800)
- Niels Kroman
- Anne‐Marie Gerdes (ORCID: https://orcid.org/0000-0002-0328-3320)
- Lisbet Rosenkrantz Hölmich (ORCID: https://orcid.org/0000-0002-1983-5222)
- Karin Wadt (ORCID: https://orcid.org/0000-0003-2882-6798)
Institutions
- University of Copenhagen (DK)
- Herlev Hospital (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
- Danish Cancer Society (DK)
Publication Details
- Journal
- Breast Cancer Research and Treatment
- Published
- 2025-09-20
- DOI
- https://doi.org/10.1007/s10549-025-07821-4
- Citations
- 1
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Kræftens Bekæmpelse
- Danish Cancer Society Research Center