Delayed Relapse of Gastric Gastrointestinal Stromal Tumor After 17 Years: A Case Report and Review of Surveillance Challenges

Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms. Complete surgical resection is the mainstay of treatment, yet recurrence remains common even after apparent complete resection. Gastrointestinal stromal tumors carry a notable long-term risk of recurrence even after surgery, underscoring the need for ongoing vigilance. We present a case of very late recurrence of gastric GIST 17 years after complete resection. This case highlights the limitations of current surveillance protocols and raises important questions about tumor biology, genetic risk stratification, and the need for long-term or even lifelong follow-up in selected patients.