Histone lactylation exacerbates acute lung injury in septic mice by promoting ferroptosis in pulmonary microvascular endothelial cells
This study revealed a critical role for high lactate-derived histone lactylation in PMVEC ferroptosis and the progression of ALI during sepsis, providing new insights and potential therapeutic mechanisms.
Authors
- Mengmeng Xu (ORCID: https://orcid.org/0000-0002-9456-6720)
- Lin Fu (ORCID: https://orcid.org/0000-0003-1069-3560)
- Qinghai You (ORCID: https://orcid.org/0000-0002-6237-9146)
- Jingjing Pan (ORCID: https://orcid.org/0000-0003-2887-9881)
- Shuai Li (ORCID: https://orcid.org/0000-0001-6664-6507)
- Gengyun Sun (ORCID: https://orcid.org/0000-0001-9099-5731)
- Pu Fang (ORCID: https://orcid.org/0000-0002-4656-3090)
- Zong-Qing Lu
- Dun-Lin Xia
Institutions
- University of Science and Technology of China (CN)
- Anhui Medical University (CN)
- Anhui Provincial Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Burns & Trauma
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/burnst/tkaf056
- Citations
- 3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56