Methionine-facilitated chalcogenation of peptides through palladium-catalyzed β-C(sp<sup>3</sup>)–H activation
We report a novel methodology for the site-selective chalcogenation of peptides <i>via</i> Pd-catalyzed β-C(sp<sup>3</sup>)-H activation. In this study, native methionine residues serve as an intrinsic directing group, while various diaryl disulfides/diselenides act as coupling partners, affording chalcogenated peptides in moderate to good isolated yields.
Authors
- Yi Sun (ORCID: https://orcid.org/0000-0001-9177-6557)
- Fengjie Lu
- Yuqi Pan
- Qi Lu (ORCID: https://orcid.org/0000-0002-1725-5398)
- Wei Qu (ORCID: https://orcid.org/0000-0002-7820-7672)
Institutions
- Qufu Normal University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc04285b
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94