Can Polygenic Risk Scores for Metabolic Syndrome Contribute to Long-Term Syndrome Development in First-Episode Psychosis Patients? A Naturalistic 21-Year Follow-Up Study
MetS PRSs showed significant relationships with metabolic disturbances in patients with FEP over a lifetime. Our findings may offer promising avenues for the PRSMetS to be integrated with relevant clinical measures for identifying the FEP patients most vulnerable to develop MetS.
Authors
- Manuel J. Cuesta (ORCID: https://orcid.org/0000-0003-0250-5718)
- Gustavo J. Gil‐Berrozpe (ORCID: https://orcid.org/0000-0002-7509-9442)
- Lourdes Fañanás (ORCID: https://orcid.org/0000-0001-6266-7706)
- Alejandro Ballesteros (ORCID: https://orcid.org/0000-0003-3097-3498)
- Lucía Moreno-Izco
- X. Ansorena
- Ana M. Sánchez-Torres (ORCID: https://orcid.org/0000-0002-9505-2406)
- Benedicto Crespo‐Facorro (ORCID: https://orcid.org/0000-0003-0033-7132)
- Lucía Janda
- Alice Roser
- Sergi Papiol (ORCID: https://orcid.org/0000-0001-9366-8728)
- David Peralta (ORCID: https://orcid.org/0000-0002-1439-4472)
- Eloi Giné-Servén (ORCID: https://orcid.org/0000-0002-3130-5566)
- Víctor Peralta (ORCID: https://orcid.org/0000-0001-6188-4258)
- Elena García de Jalón
- María Ribeiro (ORCID: https://orcid.org/0009-0000-4729-9255)
- Esther Rosado
- J. Chato
Institutions
- Universidad Pública de Navarra (UPNA) (ES)
- Servicio Navarro de Salud (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Complejo Hospitalario de Navarra (ES)
- Navarre Institute of Health Research (ES)
- Instituto de Biomedicina de Sevilla (ES)
- Max Planck Institute of Psychiatry (DE)
- Hospital Universitario Virgen del Rocío (ES)
- Medical Research Network (US)
- Universidad de Sevilla (ES)
- Ludwig-Maximilians-Universität München (DE)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Schizophrenia Bulletin
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1093/schbul/sbaf158
- Primary Topic
- Mental Health Research Topics
- Type
- article
- Field-Weighted Citation Impact
- 0.00