Altered cerebral blood flow and functional connectivity in sickle cell disease
Adults with SCD demonstrate cerebral hyperperfusion, disrupted functional connectivity, and altered spontaneous brain activity, which may contribute to cognitive slowing and heightened pain sensitivity. These findings highlight the need for further research into brain-targeted therapies in SCD.
Authors
- Daniel Sop (ORCID: https://orcid.org/0000-0003-2076-8319)
- Yue May Zhang
- Wally R. Smith (ORCID: https://orcid.org/0000-0002-4122-5367)
Institutions
- Virginia Commonwealth University (US)
- Department of General Services (US)
Publication Details
- Journal
- Journal of sickle cell disease.
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/jscdis/yoaf031
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00