Dual oncogenic roles of TPD52 and TPD52L2 in gastric cancer progression <i>via</i> PI3K/AKT activation and immunosuppressive microenvironment remodeling
TPD52 and TPD52L2 are promising prognostic biomarkers in GC, with TPD52L2 exhibiting greater clinical relevance. Targeting these proteins may disrupt oncogenic signaling pathways and enhance immunotherapy efficacy, warranting further investigation in clinical trials.
Authors
- Shougang Guo (ORCID: https://orcid.org/0000-0003-0748-6990)
- Chun‐Ting Yang (ORCID: https://orcid.org/0000-0002-5747-6806)
- Zhe Jing
- Shugeng Gao (ORCID: https://orcid.org/0000-0003-3171-5319)
- Xiaojun Liu (ORCID: https://orcid.org/0000-0002-5972-907X)
- Rong Su (ORCID: https://orcid.org/0009-0008-8139-6292)
- Ping Tang (ORCID: https://orcid.org/0000-0003-4336-4202)
- Shuping Qiu
- Jing Han (ORCID: https://orcid.org/0009-0001-9657-3481)
- Xiaqing Gao
Institutions
- Gansu University of Traditional Chinese Medicine (CN)
- Zhoukou City Academy of Agricultural Sciences (CN)
- Shenzhen Luohu People's Hospital (CN)
Publication Details
- Journal
- Briefings in Functional Genomics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/bfgp/elaf015
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Science and Technology Program of Gansu Province