Mesenchymal progenitor–derived proteoglycan 4 regulates the transdifferentiation of chondrocytes into osteoblasts during fracture healing
These findings provide new insights into the role of PRG4 in bone regeneration. PRG4, derived from Hic1+ MPCs, is critical for regulating the balance between chondrogenesis and osteogenesis during fracture repair. By preventing premature chondrocyte‑to‑osteoblast transition, PRG4 supports proper callus formation and bone healing. This work highlights the importance of PRG4 and Hic1+ MPCs in fracture repair and extends their known functions in tissue homeostasis and wound healing.
Authors
- Daphne A. Kaketsis (ORCID: https://orcid.org/0000-0002-3736-0865)
- Tannin A. Schmidt (ORCID: https://orcid.org/0000-0001-7140-254X)
- Jessica May Corpuz
- Ralph Marcucio (ORCID: https://orcid.org/0000-0002-0537-818X)
- Derrick E. Rancourt (ORCID: https://orcid.org/0000-0003-4179-345X)
- Haochen Sun (ORCID: https://orcid.org/0000-0002-4147-0346)
- Aria Ahadzadeh Ardebili
- Nicoletta Ninkovic (ORCID: https://orcid.org/0000-0002-9138-4710)
- W. Brent Edwards (ORCID: https://orcid.org/0000-0002-3623-9764)
- T. Michael Underhill (ORCID: https://orcid.org/0000-0003-3048-9102)
- Juyeon Cha
- Sarah L. Manske (ORCID: https://orcid.org/0000-0003-0888-9556)
- Alexandra Olsen (ORCID: https://orcid.org/0000-0001-9980-3468)
- Colton M. Unger (ORCID: https://orcid.org/0000-0001-6793-8173)
- Gregory D. Jay (ORCID: https://orcid.org/0000-0003-1517-8488)
- Ifaz T. Haider (ORCID: https://orcid.org/0000-0002-6445-7291)
- Jeff Biernaskie (ORCID: https://orcid.org/0000-0002-0633-0698)
- Roman Krawetz (ORCID: https://orcid.org/0000-0002-2576-4504)
- Alana Ruth Stahl
Institutions
- University of British Columbia (CA)
- University of Calgary (CA)
- University of California, San Francisco (US)
- Brown University (US)
- Alberta Children's Hospital (CA)
- Department of Physiological Sciences (RU)
- Alberta Bone and Joint Health Institute (CA)
- UConn Health (US)
Publication Details
- Journal
- Stem Cells Translational Medicine
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1093/stcltm/szaf043
- Primary Topic
- Periodontal Regeneration and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00