Human very small embryonic-like (hVSEL) stem cells and the reversal of advanced liver fibrosis

Background & aims: SONG Laser activated autologous hVSEL stem cells have shown benefits in a range of diseases including osteoporosis, spinal disk repair and neurological disorders. The aim of this work is to assess the potential role of SONG Laser activated autologous hVSEL stem cells in the treatment of liver fibrosis. The patient had liver fibrosis following previous Hepatitis C infection. Approach & results: The hVSEL stem cells were obtained from peripheral blood and activated with the SONG Laser. The SONG Laser activated hVSEL stem cells were returned to the patient by the intravenous route. The SONG Laser was then applied directly to the patient in the region of the liver. The patient was assessed by pre- and post-treatment liver biopsies. The pre-treatment liver biopsy showed Grade 4 liver fibrosis. The post-treatment liver biopsy showed Grade 1-2 liver fibrosis. No adverse events occurred and the patient remains stable. Conclusion: This is the first report of the reversal of liver fibrosis using SONG Laser activated hVSEL stem cells. Further studies are required to fully assess the safety and efficacy of SONG Laser activated hVSEL stem cells in liver fibrosis.