Efficacy of Potassium-Competitive Acid Blockers to Treat Chronic Cough Associated With “Proven” Laryngopharyngeal Reflux Disease: A Preliminary Study

This preliminary study suggested that three-month P-CAB therapy appears to be a reasonable option for patients with CC and proven LPRD diagnosed by HEMII, even if PPI therapy fails and RSI is normal, however a long-term continuous P-CAB therapy may be required. More than half of patients had normal acid exposure, which may be missed by conventional pH-metry. Since a conventional pH-metry and RSI-based diagnosis of LPRD is insufficient, HEMII may be essential to evaluate patients with CC who are suspicious of LPRD.