Mixed Aldosterone and Cortisol Secretion in Patients with Adrenal Incidentalomas: Different Faces of the Old Concept of Connshing Syndrome

Mixed aldosterone and cortisol hypersecretion is usually associated with poor BP control and metabolic disturbances, but in real clinical practice, a wide range of disorders is observed, from severe resistant hypertension to rare cases of normotension and from pronounced metabolic syndrome to a complete absence of metabolic abnormalities. Atypical presentation of A/C-CoS is more likely to be found among patients with AIs. This observation confirms the need for a comprehensive hormonal evaluation of all patients with AIs, regardless of their clinical presentation.