Synaptic ultrastructural alterations in human focal cortical dysplasia: Insights from volume electron microscopy
This study identifies distinct synaptic and subcellular structural abnormalities in FCD that may contribute to E-I imbalance and neuronal hyperexcitability. These findings provide novel ultrastructural insights into the pathophysiology of FCD and may inform future therapeutic strategies targeting synaptic and metabolic dysfunction.
Authors
- Gyu Hyun Kim (ORCID: https://orcid.org/0000-0003-0503-187X)
- Na‐Young Seo (ORCID: https://orcid.org/0000-0002-2919-9346)
- Jae‐Kyung Won (ORCID: https://orcid.org/0000-0003-1459-8093)
- Kea Joo Lee (ORCID: https://orcid.org/0000-0002-1366-4709)
- Ji Yeoun Lee (ORCID: https://orcid.org/0000-0003-0464-7605)
- Seung‐Ki Kim (ORCID: https://orcid.org/0000-0002-0039-0083)
- Yang Hoon Huh (ORCID: https://orcid.org/0000-0003-3157-304X)
Institutions
- Seoul National University (KR)
- Korea University (KR)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
- Seoul National University Children's Hospital (KR)
- Korea Basic Science Institute (KR)
- Korea Brain Research Institute (KR)
- Korea University (JP)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-09-20
- DOI
- https://doi.org/10.1111/epi.18626
- Citations
- 2
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.82