Mapping phenotypic and genetic relationships among irritability, depression and <scp>ADHD</scp> in adolescence using network analysis
Although irritability appears to be transdiagnostic, phenotypically, it was most strongly associated with headstrong/hurtful ODD items and broader behavioural problems, which favours the ICD-11 approach of including irritability as a specifier of ODD. However, irritability appeared to be a key connector between both ADHD and behavioural problems to depression; thus, is important to monitor and treat in affected youth with ADHD or behavioural problems.
Authors
- Luís C. Farhat (ORCID: https://orcid.org/0000-0002-3147-8344)
- Ellen Leibenluft (ORCID: https://orcid.org/0000-0001-8971-2087)
- Olga Eyre (ORCID: https://orcid.org/0000-0003-1944-9679)
- Anita Thapar (ORCID: https://orcid.org/0000-0002-3689-737X)
- Lucy Riglin (ORCID: https://orcid.org/0000-0002-5124-5230)
- Olakunle Oginni (ORCID: https://orcid.org/0000-0002-2340-9429)
- Amy Shakeshaft (ORCID: https://orcid.org/0000-0003-1412-5413)
- Charlotte A. Dennison (ORCID: https://orcid.org/0000-0002-7493-2041)
- Michael O’Donovan (ORCID: https://orcid.org/0000-0001-7073-2379)
- Guilherme V. Polanczyk (ORCID: https://orcid.org/0000-0003-2311-3289)
- Argyris Stringaris (ORCID: https://orcid.org/0000-0002-6264-8377)
Institutions
- Universidade de São Paulo (BR)
- Centro Universitário das Faculdades Metropolitanas Unidas (BR)
- Faculty (United Kingdom) (GB)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Fundação Faculdade de Medicina (BR)
- National Institute of Mental Health (US)
- National Institute of Mental Health (CZ)
- University College London (GB)
- Cardiff University (GB)
Publication Details
- Journal
- Journal of Child Psychology and Psychiatry
- Published
- 2025-09-20
- DOI
- https://doi.org/10.1111/jcpp.70040
- Primary Topic
- Mental Health Research Topics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Bristol
- Medical Research Council
- European Regional Development Fund
- National Institute of Mental Health