Rapamycin’s Role in Periodontal Health and Therapeutics: A Scoping Review
Rapamycin exerts a multifaceted role in periodontal health by regulating autophagy, osteogenesis, inflammation, microbial composition, and cellular senescence. Given the U.S. Food and Drug Administration's approval of rapamycin for other conditions, well-designed clinical trials are needed to establish its efficacy, optimize dosing strategies, and ensure long-term safety for periodontal therapy.Knowledge Transfer Statement:The findings highlighted in this scoping review can help researchers understand the potentially mechanistic pathways of rapamycin on periodontal tissues and guide future research on the therapeutic potential of rapamycin for the treatment of periodontitis.
Authors
- Eswar Kandaswamy (ORCID: https://orcid.org/0000-0002-6661-7930)
- Vinayak Joshi (ORCID: https://orcid.org/0000-0001-6215-4636)
- Manohar S. Kugaji (ORCID: https://orcid.org/0000-0001-6315-4531)
- Vivek Thumbigere‐Math (ORCID: https://orcid.org/0000-0002-8279-3766)
- Ganggang Shi (ORCID: https://orcid.org/0000-0002-6856-1192)
Institutions
- National Institute of Technology Karnataka (IN)
- University of Maryland, Baltimore (US)
- Rajiv Gandhi University of Health Sciences (IN)
- Sri Rajiv Gandhi College of Dental Sciences and Hospital (IN)
- Louisiana State University Health Sciences Center New Orleans (US)
Publication Details
- Journal
- JDR Clinical & Translational Research
- Published
- 2025-09-20
- DOI
- https://doi.org/10.1177/23800844251366967
- Citations
- 1
- Primary Topic
- Oral and gingival health research
- Type
- article
- Field-Weighted Citation Impact
- 2.02