Single-cell profiling of peripheral and local immune compartments reveal unique genotype-independent prognostic immune signatures across isocitrate dehydrogenase-stratified glioma
This study reveals variable expression of immune phenotypes in adult gliomas stratified by IDH status and characterizes immune compartment and genotype-dependent differences in the immunologic glioma landscape. These genotype-dependent, tumor and circulating immune ontogenies should guide future diagnostic and immunotherapeutic considerations in malignant glioma.
Authors
- Dario A.A. Vignali (ORCID: https://orcid.org/0000-0002-2771-5992)
- Kai Tan (ORCID: https://orcid.org/0000-0002-9104-5567)
- Jonathan Sussman (ORCID: https://orcid.org/0000-0002-7702-8816)
- Nduka Amankulor (ORCID: https://orcid.org/0000-0001-6217-1954)
- Wojciech K. Panek (ORCID: https://orcid.org/0000-0002-5667-5715)
- Emily Xu
- Sajeev Kohli (ORCID: https://orcid.org/0000-0001-6957-1969)
- Tullia C. Bruno (ORCID: https://orcid.org/0000-0002-6433-0207)
- Katharine Krueger
- Jonathan Patterson (ORCID: https://orcid.org/0000-0002-0475-3750)
- Angelo Angione (ORCID: https://orcid.org/0000-0001-7713-5833)
- Omar Elghawy (ORCID: https://orcid.org/0000-0002-0786-8035)
- Carly Cardello (ORCID: https://orcid.org/0000-0002-2810-7681)
- Prajwal Rajappa (ORCID: https://orcid.org/0000-0002-5911-9554)
- Bhargavi R. Budihal
- Antonio Corral Tarbay
- Ali Akbar Ghamari (ORCID: https://orcid.org/0000-0003-3082-699X)
- Anthony R. Cillo (ORCID: https://orcid.org/0000-0002-3213-3129)
- Alex Li (ORCID: https://orcid.org/0000-0001-7101-4547)
- Ebrar Akca
- Xiaoran Zhang (ORCID: https://orcid.org/0000-0002-4654-6055)
- Jessica Xu (ORCID: https://orcid.org/0000-0003-2587-9587)
- David H. Moon
Institutions
- Nationwide Children's Hospital (US)
- Children's Hospital of Philadelphia (US)
- University of Pittsburgh (US)
- Hospital of the University of Pennsylvania (US)
- The Ohio State University Wexner Medical Center (US)
- Parker Institute for Cancer Immunotherapy (US)
- UPMC Hillman Cancer Center (US)
- University of Pittsburgh Medical Center (US)
- BGS Global Hospital (IN)
- Institute of Medical Sciences (IN)
- University of Pennsylvania (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1093/neuonc/noaf206
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- University of Pennsylvania
- University of Pittsburgh
- National Institutes of Health
- Center for Research Computing, University of Pittsburgh
- National Cancer Institute