Catalyst-Controlled Switchable Mono-/Di-C–H Arylation of Aromatic Amides with Arylsilanes
The selective mono/di-C-H arylation of aromatic amides has been developed, enabling efficient coupling with arylsilanes under mild conditions with good functional group tolerance. The regioselectivity (mono- vs diarylation) is catalyst-dependent, with [Cp*RhCl<sub>2</sub>]<sub>2</sub> selectively promoting monoarylation, whereas [Cp*IrCl<sub>2</sub>]<sub>2</sub> demonstrates a distinct preference for diarylation. This approach establishes a straightforward and efficient strategy for the late-stage arylation of pharmaceutical compounds.
Authors
- Yi Dong (ORCID: https://orcid.org/0000-0001-7844-7206)
- Tingting Hou (ORCID: https://orcid.org/0009-0000-1736-9419)
- Wenwu Liu (ORCID: https://orcid.org/0009-0003-7509-2157)
- Heng Xu (ORCID: https://orcid.org/0000-0002-1720-5286)
- Ming‐Chun Lu (ORCID: https://orcid.org/0000-0001-5293-0718)
- Xin Yang (ORCID: https://orcid.org/0009-0000-9693-1325)
- Deyu Wu
- Mengmeng Li (ORCID: https://orcid.org/0000-0002-6317-875X)
Institutions
- Guiyang Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking Union Medical College Hospital (CN)
- Shanghai Institute of Materia Medica (CN)
- Peking University First Hospital (CN)
- Institute of Medicinal Plant Development (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-09-20
- DOI
- https://doi.org/10.1021/acs.orglett.5c03239
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94