Liver fat mediates hippocampal-orbitofrontal reward circuit disruption and cognitive-emotional impairments in MASLD
MASLD-related brain atrophy and functional disruption are linked to visceral adiposity and neuropsychiatric deficits. The mediating role of liver fat highlights the importance of dual-pathway interventions that target both metabolic health and neural protection, potentially reducing long-term neurocognitive disability burdens and enabling accessible risk stratification in practice.
Authors
- Kuanghui Xu
- Liqiang Wu (ORCID: https://orcid.org/0000-0001-6754-8175)
- Ruiyi Tang (ORCID: https://orcid.org/0000-0001-7091-7832)
- Xiaofei Chen (ORCID: https://orcid.org/0000-0002-6252-5879)
- Jie Li (ORCID: https://orcid.org/0000-0002-2636-9012)
- Yidan Liang
- Yihan Jin
- Junping Shi (ORCID: https://orcid.org/0000-0002-1356-4994)
Institutions
- Affiliated Hospital of Hangzhou Normal University (CN)
- Zhejiang Hospital (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1186/s12944-025-02728-x
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71