Temporal evolution of publication bias in drug safety assessment: A case study on association between osteonecrosis of the jaw and bisphosphonates
Although publication bias decreased over time, its impact persisted for 17years. Consequently, risk perception may remain distorted for an extended period. This observation mirrors the dynamics of pharmacovigilance alerts, which often rely on initial publications. When publication bias is identified in previous meta-analyses, future updates should carefully reassess its presence, even many years later.
Authors
- A. Lajoinie (ORCID: https://orcid.org/0000-0001-8712-8813)
- François Gueyffier
- E. Massy
- Maëlys Granal
- A. Gougeon (ORCID: https://orcid.org/0009-0009-6941-730X)
- Jean‐Christophe Lega (ORCID: https://orcid.org/0000-0002-9398-2968)
- Guillaume Grenet (ORCID: https://orcid.org/0000-0002-5237-2581)
- Marine Auffret
- Nazan Aksoy
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Hospices Civils de Lyon (FR)
- Laboratoire de Biométrie et Biologie Evolutive (FR)
Publication Details
- Journal
- Joint Bone Spine
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1016/j.jbspin.2025.105970
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00