Effects of 2-year cocoa extract supplementation on inflammaging biomarkers in older US adults: findings from the COcoa Supplement and Multivitamin Outcomes Study randomised clinical trial
Cocoa extract supplementation significantly decreased hsCRP, supporting a role in modulating the chronic inflammaging process as a potential mechanism underlying its cardio-protective effects, including a 27% reduction in cardiovascular disease death in the COSMOS trial. The biological effect of increased IFN-γ by cocoa extract warrants further exploration.
Authors
- Pamela M. Rist (ORCID: https://orcid.org/0000-0003-3543-045X)
- Howard D. Sesso (ORCID: https://orcid.org/0000-0002-9698-9954)
- Sidong Li (ORCID: https://orcid.org/0000-0002-4798-8920)
- Rikuta Hamaya (ORCID: https://orcid.org/0000-0003-1635-1983)
- Haidong Zhu (ORCID: https://orcid.org/0000-0002-8384-0464)
- JoAnn E. Manson (ORCID: https://orcid.org/0000-0002-9426-7595)
- Yanbin Dong (ORCID: https://orcid.org/0000-0001-7848-7160)
- Ying Huang (ORCID: https://orcid.org/0000-0001-8532-9494)
- Allison Clar
Institutions
- University of Science and Technology of China (CN)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Augusta University (US)
- Prevention Institute (US)
Publication Details
- Journal
- Age and Ageing
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1093/ageing/afaf269
- Citations
- 4
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 5.42