Retinal and Choroidal Changes in Transthyretin-Related Amyloidosis Using Optical Coherence Tomography Modalities: A Systematic Review
Thinning of ONL was the most consistent structural finding, suggesting photoreceptor degeneration. Decreased CVI, reduced vascular density, and enlargement of the FAZ further indicate impaired vascular integrity. Although OCT and OCT-A show promise for early detection and monitoring of ocular involvement in ATTR, most studies were case-control studies with small sample sizes and possible confounding from ongoing treatments. These limitations highlight the need for standardized imaging protocols and longitudinal studies to confirm findings and clarify the link between ocular and systemic disease severity.
Authors
- Chiara Giuffré (ORCID: https://orcid.org/0000-0003-0839-2670)
- Maria Vittoria Cicinelli (ORCID: https://orcid.org/0000-0003-2938-0409)
- Costanza Barresi (ORCID: https://orcid.org/0000-0003-4828-7170)
- Makan Ziafati (ORCID: https://orcid.org/0000-0002-9727-4459)
Institutions
- Vita-Salute San Raffaele University (IT)
- Iranian Institute for Health Sciences Research (IR)
- Farabi Hospital (IR)
- Iranian Center for Quantum Technologies (IR)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- Tehran University of Medical Sciences (IR)
- University of Palermo (IT)
Publication Details
- Journal
- Ophthalmology and Therapy
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1007/s40123-025-01240-w
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00