Synergistic inhibitory effects of <i>Trifolium pratense</i> L. extract and doxorubicin on 4T1 tumor-bearing mice are mediated via targeting the Wnt/β-catenin pathway and reversal of epithelial-mesenchymal transition.
<i>T. pratense</i> extract shows potential as an adjuvant therapy against TNBC by targeting the Wnt/β-catenin pathway and reversing EMT while enhancing DOX efficacy. Further research is warranted to explore additional anticancer mechanisms of <i>T. pratense</i> extract.
Authors
- Elham Niromand (ORCID: https://orcid.org/0000-0001-6406-6779)
- Mohammad Hossein Faraji
- Mohammad Rasool Khazaei (ORCID: https://orcid.org/0000-0001-9818-0625)
- Saeed Khazayel (ORCID: https://orcid.org/0000-0002-0778-4552)
- Mozafar Khazaei (ORCID: https://orcid.org/0000-0003-2288-4938)
- Mohsen Akbaribazm (ORCID: https://orcid.org/0000-0001-9162-8706)
Institutions
- Shiraz University (IR)
- Kermanshah University of Medical Sciences (IR)
- Islamic Azad University, Khoy Branch (IR)
Publication Details
- Journal
- PubMed
- Published
- 2025-09-19
- DOI
- https://doi.org/10.22038/ajp.2025.25940
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00