F2 peptide fraction of <i>Androctonus crassicauda</i> scorpion venom: Inducing M2 to M1 macrophage polarization and inhibiting colon carcinoma cell proliferation and migration.
Our results suggest that the F2 fraction of <i>A. crassicauda</i> scorpion venom reprograms tumor-associated M2 macrophages towards an anti-tumor M1 phenotype. These findings suggest the potential of the F2 fraction of <i>A. crassicauda</i> scorpion venom as a novel therapeutic strategy for the treatment of colon cancer. However, to confirm this potential, further <i>in vivo</i> studies need to be carried out.
Authors
- Nooshin Ghadiri (ORCID: https://orcid.org/0000-0003-2370-3385)
- Ali Khodadadi (ORCID: https://orcid.org/0000-0003-0442-273X)
- Ata Ghadiri (ORCID: https://orcid.org/0000-0001-7431-7439)
- Mohammad Rashno (ORCID: https://orcid.org/0000-0001-5473-1384)
- Ali Asadirad (ORCID: https://orcid.org/0000-0002-7203-343X)
- Mohammad Nemati
Institutions
- Ahvaz Jundishapur University of Medical Sciences (IR)
- Razi Vaccine and Serum Research Institute (IR)
- Agricultural Research & Education Organization (IR)
Publication Details
- Journal
- PubMed
- Published
- 2025-09-19
- DOI
- https://doi.org/10.22038/ajp.2025.25721
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ahvaz Jundishapur University of Medical Sciences